Weakness of the arm and hand after stroke affects peoples' everyday lives

Some treatments may be beneficial but this largely depends on a patient's ability to participate actively in repetitive practice of everyday (functional) tasks. Patients with substantial weakness may not be able to do this.

FAST INdICATE investigates whether functional strength training (FST) can reduce weakness and thereby enhance outcome.

We know that central nervous system (CNS) recovery involves reorganisation of nerve networks in the brain and spinal cord.

However, we do not yet know how to use physical therapies to encourage reorganisation to improve outcomes after stroke.

We also do not know which stroke survivors should receive which physical therapies.

Therefore, FAST INdICATE hopes to answer these questions by combining brain imaging, to define the extent of damage, and brain activity during hand movement and TMS to measure how well the brain communicates with the weakened muscles of the effected arm and hand.